If you’ve been hearing buzz about “polynucleotide” injections and wonder whether they’re right for you, this guide breaks it down in plain English — with a local focus on Dulwich (East/West/Crystal Palace area) so you know what to expect nearby.
What are polynucleotides?

Polynucleotides (often shortened to “PN”) are tiny fragments of DNA derived and highly purified for medical/aesthetic use. They’re used as injectable skin boosters rather than traditional fillers. The idea is not to plump like hyaluronic acid fillers, but to encourage the skin’s own repair processes — improving hydration, elasticity, texture, and helping fade fine lines and acne scars over time. Several well-known brand names you may see in clinics include Rejuran (Korean origin), Nucleofill, and other PN skin boosters. Evidence summarized in recent reviews shows promising results for skin rejuvenation, though results and protocols vary.
How do polynucleotide treatments work?
PN injections are placed into the dermis using a series of small micro-injections. Polynucleotides are thought to:
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Activate fibroblasts (the cells that produce collagen and elastin),
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Improve microcirculation and tissue repair,
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Increase hydration and skin elasticity.
Because PNs act by stimulating biological repair rather than mechanically filling space, improvements typically build over weeks and can last several months depending on the product and course of treatments. Clinical studies and reviews report improvements in firmness, texture, pigmentation and patient satisfaction with a generally favourable safety profile.
Is it offered near Dulwich?
Yes — several aesthetic clinics in and around Dulwich / South London list polynucleotide or Rejuran-style skin boosters as part of their services. Clinics serving East Dulwich and nearby Crystal Palace advertise PN treatments and skin-boosting packages. If you live in Dulwich, you’ll usually find options within a short drive or Tube/bus ride, and many clinics offer consultations to see whether PN is the right choice for your skin concerns. Always check practitioner qualifications and read recent patient reviews.
Typical treatment course and what to expect
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Consultation: A qualified clinician assesses your skin, medical history, and expectations. They’ll discuss realistic outcomes and consent.
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Number of sessions: Many clinics recommend a course of 2–4 sessions spaced 3–4 weeks apart for best results, then maintenance treatments every 4–6 months depending on response.
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Procedure time: Usually 20–45 minutes depending on areas treated.
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Discomfort: Treatments use very fine needles; most clients report only mild discomfort. Topical numbing can be used.
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Downtime: Minimal. Expect temporary redness, a few pinpoint bruises or mild swelling for 24–72 hours. Rarely, small nodules can appear but usually resolve.
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When results appear: Early improvements in hydration and radiance can be seen within 1–2 weeks; collagen-related changes develop over several weeks to months.
Benefits people notice
Clients commonly report:
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Smoother skin texture,
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Better hydration and glow,
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Reduced fine lines and improved elasticity,
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Improvement in acne-scarred areas and skin tone over time.
The appeal of PN is a more “biological” or natural rejuvenation rather than dramatic volumizing. Clinical reviews indicate meaningful improvements, especially for skin quality and elasticity.
Risks and safety
Polynucleotide treatments are generally well tolerated, but as with any injection, risks include:
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Redness, mild swelling, bruising,
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Temporary lumps or nodules (usually resolve),
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Infection (rare) — minimized by proper clinical hygiene,
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Allergic reaction — very uncommon, but discuss allergies and medical history in consultation.
Choosing a regulated clinic with trained, insured practitioners reduces risk. Avoid bargain or non-medical providers. If you have active skin infections, certain autoimmune conditions, or are pregnant or breastfeeding, tell your clinician — PN might not be appropriate.
Cost (ballpark)
Prices vary by clinic, brand, and treatment area. In London, a single PN session often ranges from roughly £200–£450 per session depending on the product and clinic reputation. Many clinics offer package pricing for multiple sessions. Always get a written treatment plan and breakdown of costs before proceeding. (Local Dulwich clinics may be priced toward the lower or middle end of central London rates, but confirm with the clinic.)
Choosing the right clinic in Dulwich
A quick checklist:
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Confirm practitioner credentials (doctor, dentist with facial aesthetics training, or accredited nurse prescriber).
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Check the clinic’s reviews and before/after galleries.
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Ask which PN brand they use (Rejuran, Nucleofill, etc.) and for product information.
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Ensure they offer a proper consultation, clear aftercare instructions, and emergency contact.
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Ask about expected number of sessions and maintenance schedules.
Local clinics around East Dulwich and Crystal Palace advertise PN treatments — book consultations at a couple of reputable places to compare approach and pricing.
Aftercare tips
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Avoid strenuous exercise, saunas, and heavy alcohol for 24–48 hours after treatment.
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Keep treated areas clean and avoid makeup for 12–24 hours if advised.
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Use gentle skincare, sunscreen, and follow any topical regimen your practitioner recommends.
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Report persistent swelling, increasing pain, high fever, or signs of infection promptly.
Final thoughts
Polynucleotide skin boosters represent an interesting advance in aesthetic medicine — working with your skin’s biology to encourage repair and quality improvement rather than simply filling lines. Recent clinical reviews are promising for skin texture, elasticity and overall rejuvenation, and many clinics across London (including providers serving the Dulwich area) now offer these treatments. If you’re curious, start with a professional consultation to confirm suitability, set realistic expectations, and choose a qualified provider.



